NIH R01 · 2025
Crosstalk between butyrophilins and gamma delta T cells in human cancer
Differences between mouse and human γδ T cells have hindered a better understanding of the role of these innate lymphocytes in human cancer, due in part to the lack of relevant transgenic models. Key advances in the previous funding cycle of this grant underscored the crucial role of γδ T cells in human ovarian cancer and how butyrophilins govern their phenotypes. Building upon our new preliminary results, our central hypothesis is that that BTNL9, in a lipid-dependent manner, activates crucial subsets of anti-tumor δ1 T cells in an “innate-like”, CDR3-independent fashion, through binding to specific variable γ regions. Furthermore, novel allogeneic cellular therapies using…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.