NIH R01 · 2025
Uncovering novel players in nucleolar organization and function
PROJECT SUMMARY The nucleolus is one of the largest membraneless cellular organelles, responsible for ribosomal RNA (rRNA) transcription, rRNA processing, and ribosome assembly. Nucleolar size and number are often correlated with protein synthesis rate and proliferative capacity of a cell. Seminal studies have shown that increased nucleolar size and number are common features of many cancers and that nucleolar defects are associated with neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Nevertheless, fundamental information is still lacking on the molecular players and mechanism that control the dynamic assembly and activity of the nucleolus in health and disease.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.