NIH R01 · 2025
A Pre-, Peri-, and Post-natal Approach to Understanding the Risk and Mechanisms for Obesity
Project Summary Although obesity is a serious threat to the nation’s health, little progress has been made in its prevention. Infancy may be an opportune time to prevent its development since the sooner the trajectory towards obesity is halted, the less likely that negative health consequences will arise. Altered early gut bacterial communities may influence offspring obesity through the metabolites they produce. Our overarching working causal model is that pre-, peri- and postnatal exposures alter the microbes that colonize the infant’s gastrointestinal tract, which in turn alters the gastrointestinal metabolites available to the infant host thereby programming that infant for a lifetime…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.