NIH R01 · 2025
Protective mechanisms of the gut Bacteroidales
Project Summary Our long-term objectives are to understand genetic and phenotypic properties that allow the abundant human gut Bacteroidales species to survive in the host over its lifetime. In this proposal, we will build upon our work studying antibacterial toxins produced by the gut Bacteroidales that they use to antagonize other members of ecosystem. We will study important protective responses mounted by these bacteria upon exposure to antibacterial toxins and other stressors they encounter in the gut microbiota. We found that the genes of an unusual ECF-type sigma factor/antisigma factor pair, named EcfO-Reo, are induced upon exposure of Phocaeicola vulgatus to toxins and other…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.