NIH R01 · 2025
Molecular mechanisms of motor skill stabilization
PROJECT SUMMARY Successful motor skill learning is marked by decreased performance variability over time. For motor skills learned during early developmental time periods, such as walking and talking, performance remains highly stable and precise throughout life, suggesting that associated motor circuits exist in a stable state that is tuned to performance. Motor skill stabilization has been studied in terms of changes to neural population coding, neurophysiology, and synaptic plasticity, yet the molecular mechanisms that transition motor circuits to a state that supports stable motor performance are unknown. Like developmental motor skills in humans, the song of the Bengalese finch, an…
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