Colonnese Lab

George Washington University

PHARMACOLOGY

Washington · United States

NIH-funded
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NIH R01 · 2025

Circuit specializations of developing visual networks

The visual pathways of the human fetal brain are highly active before birth. During this pre-visual period spontaneous activity in the retina provides the primary input to visual brain and data from neonatal rodents implicate this early activity in normal development and organization of visual pathways. While we understand much about the specialized circuits that produce activity in the developing retina, and the consequences of disruption of that activity for eye and brain outcomes, we know little of the brain activity that supports the earliest stages of sensory development. Early retinal activity is not passively transmitted in the developing brain. Rather, it is actively amplified and…

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