NIH R01 · 2025
Harnessing nutrition to enhance vaccine responses
PROJECT ABSTRACT Novel pathogens (e.g., SARS-CoV2, monkeypox, respiratory syncytial virus, and influenza) are constantly emerging, creating an urgent, unmet need to identify strategies that enhance immunological memory. Our previous work demonstrated that caloric restriction (CR) is a nutritional intervention that enhances immunological memory in mice, resulting in 500-fold greater pathogen control (Collins N, Cell, 2019 and Han SJ…Collins N*, PNAS, 2023). However, the molecular determinants, signaling pathways, and cell-cell interactions involved are unknown. The objective of this proposal is to generate fundamental mechanistic information that fills these gaps in knowledge, which will…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.