NIH R01 · 2024
Characterizing sexual development of the human parasite Schistosoma mansoni
Schistosomiasis is a neglected tropical disease caused by parasitic flatworms, called schistosomes, that affects hundreds of millions of the world’s poorest people. The pathology of this disease stems from the fact that schistosomes can lay hundreds-to-thousands of eggs per day while living in the blood vessels of their human hosts. Therefore, understanding the mechanisms that control schistosome egg production could present new opportunities to both limit the spread of the disease and abrogate the pathology caused by the parasite. Interestingly, female schistosomes only become sexually mature when they are in constant physical contact with a male worm. Indeed, females grown in the absence…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.