NIH R01 · 2024
Regenerative and degenerative responses to axonal injury
Project Summary/Abstract: Axons form connections between neurons over great distances in the brain and body, hence are vulnerable to damage and stress. This project studies an evolutionarily conserved stress response pathway that becomes activated in multiple scenarios of axonal damage and stress. The pathway, governed by the dileucine zipper kinase DLK, known as Wallenda (Wnd) in Drosophila, engages structural plasticity mechanisms in neurons that allow circuits to adapt to axon damage. These responses include axonal regeneration, neuronal death, and, newly discovered in this project, synapse loss. The long-term goals of this project are (1) to understand the mechanisms that lead to DLK…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.