NIH R01 · 2025
PROJECT SUMMARY/ABSTRACT Maternal infections during pregnancy lead to adverse outcomes for the offspring, including short-term outcomes such as intrauterine fetal demise, preterm delivery and neonatal sepsis, and long-term sequelae such as neurodevelopmental impairment. A key factor contributing to fetal/neonatal susceptibility to infection is the failure to robustly produce innate immune cells such as neutrophils that form a first line of defense against infection. We recently made the novel observation that fetal hematopoietic stem and progenitor cells (HSPCs) are extrinsically restricted from activating the pathways that would lead to rapid production of neutrophils, termed emergency…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.