NIH R01 · 2024
SGK1 is a regulator of islet beta cell mass and secretory function
Pancreatic beta-cell mass expansion occurs in the early stages of obesity and insulin resistance. Conversely, humans with diabetes have reduced numbers and diminished function of pancreatic beta-cells, indicating that islet beta-cell expansion and loss are dynamic processes subject to signal-induced regulation. Using external cues that signal demand for insulin, or that produce insulin resistance, we queried changes in gene expression in rodent and human beta-cells for inducible genes linked with growth and proliferation pathways. This approach yielded the serum and glucocorticoid inducible kinase 1 (SGK1), which is rapidly upregulated after exposure to cytokines, glucose, glucocorticoids,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.