NIH R01 · 2025
Retinoid Signaling and Homeostasis in the Eye
SUMMARY This proposal describes experiments to investigate the role played by STRA6 in modulating transcription of genetic pathways in the RPE. Mutations in human STRA6 are associated with Matthew-Wood syndrome, whose symptoms include microphthalmia-anophthalmia, as well as pulmonary hypoplasia. STRA6 is found on the surface of many blood-tissue barrier epithelia, including the RPE. Though almost exclusively described as a retinoid transporter, STRA6 also is a cytokine signaling receptor, whose function in this role has only been studied in non-ocular tissues. This provokes exciting speculation into its role in the RPE of the eye: what molecular signaling is controlled by STRA6 in the RPE?…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.