NIH R01 · 2025
Deciphering the Molecular Mechanisms of Neurotransmitter Transport
Abstract A large and increasing number of people in the US are impacted by neurological disorders, such as major depression, anxiety, autism, Parkinson’s disease, and attention deficit disorder; moreover, the global burden of disease attributable to drug addiction continues to rise. Decades of research and drug development have shown that these diseases and disorders can be treated using drugs that modulate neurotransmitter availability. Many of these therapeutics block neurotransmitter reuptake or antagonize receptor signaling by acting on plasma membrane transporters and receptors. Unfortunately, many highly addictive substances such as amphetamines also bind to these proteins, but their…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.