NIH R01 · 2025
L-type channel trafficking and modulation in heart
SUMMARY Ca2+ influx through voltage-dependent L-type (CaV1.2) channels into cardiomyocytes is a multi-dimensional signal that mediates excitation-contraction (E-C) coupling, controls action potential duration, and regulates gene expression. Dysregulation of CaV1.2 causes heart disease, the leading cause of death in the US and worldwide. β-adrenergic up-regulation of CaV1.2 underlies the positive inotropic response essential for the fight or flight response. Despite decades of intense focus, the precise molecular mechanisms underlying β-adrenergic up- regulation of Ca2+ influx via CaV1.2 in cardiomyocytes remained elusive and controversial. In the last funding period, using an…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.