NIH R01 · 2024
Enhancing Innate Anti-Viral Resistance Through A Community-Based Intervention
Project Summary The SARS-CoV-2/COVID-19 pandemic has disproportionately impacted older socioeconomically disadvantaged African-Americans. This research will test whether a recently developed community-based intervention program known as Generation Exchange (GenX) can enhance a key biological mediator of antiviral resistance (Type I interferon response) in this disadvantaged population. Our previous research has identified a stress-triggered genomic program known as the “Conserved Transcriptional Response to Adversity” (CTRA). The CTRA is activated by fight-or-flight stress responses and causes immune cells to reduce antiviral activity and stimulate inflammation, both of which are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.