NIH R01 · 2025
Chemical Approaches to Cell Signaling Enzymes
Abstract This is a competing renewal application of our longstanding R01 Grant CA74305 that concerns the development and application of chemical approaches to enhance the understanding of cell signaling pathways and the attachment, removal, and function of protein post-translational modifications (PTMs). In the next cycle, we plan to investigate how ubiquitination regulates two key cancer-related signaling enzymes, PTEN and Akt, how several cancer-connected E3 ubiquitin (Ub) ligases target and catalyze Ub transfer to their protein substrates, and how mTORC2 phosphorylates its major substrate Akt. PTEN is one of the most commonly mutated tumor suppressor genes and catalyzes the conversion of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.