NIH R01 · 2025
Astrocyte RNA degradation and cognitive function
PROJECT SUMMARY Despite its putative link to many mental illnesses, Nonsense-Mediated mRNA Decay (NMD) represents a relatively unexplored mechanism for regulating mRNA stability in brain function. NMD functions in a tissue-, cell type- and cell-state specific manner and modulates stability of selective mRNAs to fine-tune transcript abundance. There is dearth of knowledge regarding the identity of such NMD target RNAs, particularly in cells in their normal in vivo context. A particularly large gap in the field is the cell-specific function and targets of NMD in vivo. Our recent work has established that neuronal NMD regulates GLUR1 signaling and is required for proper synaptic plasticity,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.