NIH R01 · 2025
We propose to discover opportunities for Alzheimer’s Disease (AD) prevention at multiple points in the life- course: before birth, adolescence, and in midlife. We hypothesize that in utero exposure to environmental toxicants leads to cognitive dysfunction in midlife that is accompanied by changes in the serum metabolome and blood biomarkers associated with cognitive dysfunction and prodromal AD. We propose that metabolomics will reveal novel, actionable midlife biomarkers for AD prevention for persons at increased risk for AD. Our previous studies show that decline in cognition is linked to decline in plasma glutathione (GSH), which is best represented in stored plasma by associated changes…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.