NIH R01 · 2024
Metformin-Regulated Mitochondrial Peptides and their Effects on Aging
Metformin has healthspan and lifespan enhancing effects in model organisms and is a candidate therapy for aging in humans. The exact mechanism of action of metformin is poorly understood, but the mitochondrion is clearly a critical metformin target involving modulation of respiratory-chain function attributed to inhibition of Complex-1 as well as other mitochondrial actions on fission, reactive oxygen species production, etc. Our lab described the presence of multiple small open reading frames (smORFs) within mitochondrial DNA that encode a novel class of mitochondrial-derived peptides (MDPs). These MDPs have diverse cellular actions, often leading to improved metabolism, cytoprotection,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.