NIH R01 · 2025
Regulation of MutL-gamma function in mediating crossing over in mammalian meiosis
During prophase I of meiosis, crossovers (COs) ensure that parental homologs remain connected until the first meiotic division, when they must segregate equally into two daughter cells. Errors in CO formation and distribution are largely responsible for the very high rates of aneuploidy in humans. COs are initiated by the formation of DNA double strand breaks (DSBs) in early prophase I, but the number of DSBs are in huge excess relative to the final number of COs. In mammals, most COs are generated through the action of the DNA mismatch repair (MMR) pathway, including the MutSγ (MSH4/MSH5) and MutLγ (MLH1/MLH3) heterodimers. Of the 250 DSBs that form, ~150 load with MutSγ in early prophase…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.