NIH R01 · 2025
PROJECT SUMMARY: Trauma remains the leading cause of death for individuals aged 1 to 54, with a significant proportion of these fatalities attributed to trauma-induced coagulopathy (TIC) and a dysregulated inflammatory response, termed thromboinflammation. Advancements in resuscitation have lacked a mechanistic focus, instead, focusing on mitigating the adverse effects of crystalloid fluids, optimizing the use of blood products, and non-selectively addressing clot formation and fibrinolysis. Consequently, improvements in outcomes among trauma patients have plateaued. Further, efforts have failed to address trauma-associated thromboinflammation, which is the primary driver of late-stage…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.