NIH R01 · 2024
Structure-function cell atlas for norepinephrine and serotonin neurons
Project Abstract Norepinephrine (NE) and serotonin (5-HT) are neurotransmitters released by a small number of neurons in the locus coeruleus (LC) and dorsal raphe (DR), respectively. Each group of neurons provides extensive innervation of most of the brain. Although these groups of cells are often considered to be homogenous, recent data indicates the existence of subclasses of each neuron. This proposal aims to generate multi-scale data on each system, comprising molecular, genetic, anatomical, physiological, and behavioral experiments. Our team is in a unique position to integrate across experiments and develop a new understanding of the subclasses of LC-NE and DR-5-HT neurons and their…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.