Cohen Lab

University of Pittsburgh at Pittsburgh

PSYCHIATRY

Pittsburgh · United States

NIH-funded
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Research focus

NIH R01 · 2025

Predictors of Altered CNS Structure, Function, and Connectomics in the Elderly using a Health Disparities Framework

Abstract The goal of this project is to leverage the diverse sample in our Human Connectome Project (HCP) Study, Connectomics in Brain Aging (COBRA) , to investigate the role(s) of structural and social determinants of health in the natural history of Alzheimer’s Disease (AD) utilizing a health equity framework. We propose that racial inequities in the development of cognitive impairments in the context of AD are driven by pervasive structural and institutionalized inequities that shape risk and disadvantage at multiple levels, including biological, environmental, behavioral, sociocultural, as proposed in the NIA Health Disparities Research Framework. Our organizing principle is that the…

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