NIH R01 · 2025
Systems-Level Dysconnectivity in First Episode Psychosis
Schizophrenia (Sz) is a debilitating major mental illness with life-long disability that disproportionately burdens the healthcare system and society. Despite decades of research, the underlying mechanisms of pathophysiology in Sz are unknown. Attempts for determining brain abnormalities in Sz have gone beyond searching for one to a few lesion locations to focusing on functional (dys)connectivity between systems-level brain circuits and the associated neural events that underlie the failure in functional integration of information across distributed circuits. Effective connectivity refers to the influence of activity in one area on activity in another at a later time, allowing inferences…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.