NIH R01 · 2025
Project Summary/Abstract The flavivirus St. Louis encephalitis virus (SLEV) infects humans to cause febrile illness and rare fatal encephalitis. In California (CA), although human SLEV cases were detected from the 1940s-2003, none were reported from 2004-2015. Since 2015, SLEV reemerged and spread to cause more cases in CA and the Western US, including in areas with concurrent West Nile virus (WNV), a related flavivirus that invaded CA in 2003 that uses the same Culex vectors and avian hosts as SLEV. The reasons for the 11-year disappearance of SLEV from CA and its expansion since 2015 are unclear. Spread of WNV across the US was facilitated by augmented avian infection and enhanced vector…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.