NIH R01 · 2024
Interferon-inducible cell-autonomous immunity to cytosolic bacterial pathogens
Human cells including epithelial cells are equipped with cell-autonomous host defense programs providing protection against intracellular pathogens. These host protective programs are controlled in a temporal and spatial manner and respond to extracellular cues including pro-inflammatory cytokines released by professional immune cells. Arguably, the most potent inducer of antibacterial cell-autonomous host defense is lymphocyte- derived interferon-gamma (IFN). IFN-receptor signaling in human epithelial cells induces the expression of hundreds of IFN-stimulated genes (ISGs) encoding antimicrobial proteins. While a few ISGs have been studied in much detail, our understanding of most ISGs…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.