NIH R01 · 2024
Identification of trans-regulatory elements controlling MAPT transcription
Project Summary/Abstract Tau, coded for by the gene MAPT, can aggregate in the brain and is associated with many neurodegenerative diseases. Evidence suggests that the level of expression of MAPT (tau) can be genetically associated with disease risk. Furthermore, simply reducing the level of tau may be beneficial. There are many ways this may be done, but one drawback of current approaches has to do with drug delivery. The brain can be difficult to reach with therapeutics effectively, and some therapies for the brain can require invasive procedures that are not ideal for a vulnerable population such as for individuals with neurodegenerative diseases. So, it may be better to find a way to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.