NIH R01 · 2025
Production and progression of premalignant retinoblastoma lesions.
Project Summary Most cancers develop from premalignant lesions that progress to malignancy in response to further mutations or epigenetic changes. A better understanding of malignant progression may enable approaches to suppress tumorigenesis, especially in individuals with specific cancer predispositions. This project aims to define mechanisms through which premalignant lesions form and progress to malignancy in the childhood retinal cancer, retinoblastoma. In this cancer, biallelic loss of RB1 is thought to enable the aberrant proliferation of early maturing cone precursors (emCPs), which then form largely quiescent premalignant lesions in utero, followed by emergence of retinoblastoma…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.