NIH R01 · 2024
Longitudinal dynamics of protection after influenza infection and vaccination
PROJECT SUMMARY Individuals’ adaptive immune responses are central to the epidemiology and evolution of influenza and the effectiveness of influenza vaccines. It is therefore surprising that despite nearly 70 years of study, major questions about the immune response to influenza remain unanswered. In particular, it is unclear how well natural infection protects from reinfection with the same or related types and subtypes, how vaccination affects protection against symptomatic and asymptomatic infections over time, and how protection varies with immune history, age, individual, sex, and other factors. The two main obstacles to progress have been a shortage of observations from the same…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.