NIH R01 · 2024
Project Summary: Viral respiratory infections are a leading cause of hospitalization in children. In the absence of co-morbidities, children are much more likely than adults to require hospitalization for most respiratory viruses, including influenza A virus (IAV). Age-related changes in innate immune signaling over the first few years of life likely impact the course of viral respiratory infections, but the mechanisms driving viral-induced respiratory failure in children are unknown. Viral load has not been associated with severity of illness in children with IAV pneumonia, so failure to control viral replication is not likely the primary driver of severe illness in children. We have found…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.