NIH R01 · 2025
Cellular and Molecular Mechanisms of Cochlear Innervation
PROJECT SUMMARY Synaptic connections between spiral ganglion neurons (SGNs) and hair cells in the cochlea are critical for hearing and lost in many forms of hearing impairment. These synapses form prior to hearing onset and are activated by supporting cell-induced, intrinsically generated activity that is prominent within the developing cochlea. This periodic and spontaneous synaptic activity initiates SGN burst firing, which promotes SGN survival, SGN maturation, and development of frequency tuning in central auditory circuits. Our prior studies revealed an unexpected role for otic mesenchyme cells (OMCs) in establishing appropriate SGN-hair cell connectivity through activation of POU3F4,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.