NIH R01 · 2025
The Fbw7 ubiquitin ligase network: normal and neoplastic functions
This application focuses on Fbw7, an E3 ubiquitin ligase and tumor suppressor, and on its substrate c-Myc (hereafter, Myc), an oncogenic transcription factor widely implicated in human cancers. E3 ligases mark protein substrates for degradation through ubiquitin conjugation. Fbw7 recognizes a network of proteins with crucial roles in proliferation, differentiation, metabolism, and apoptosis. Fbw7 substrates include important oncoproteins (e.g., cyclin E, Notch, Myc, Jun) and thus Fbw7 mutations promote tumorigenesis by deregulating its oncogenic substrates. The Fbw7 pathway therefore has broad implications for cancer biology and for the development of new therapeutic strategies. We will…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.