NIH R01 · 2024
Cell Surface Polymer Display in Gram-Positive Bacteria
Project Summary Gram-positive bacteria are surrounded by a thick peptidoglycan cell wall that is covalently affixed with a diverse array of macromolecules that maintain cell integrity and promote effective interactions with the environment. In clinically important bacterial pathogens, these macromolecules function as essential virulence factors. Our research will investigate how bacteria elaborate their surfaces with adhesive pili and cell wall glycopolymers that are critically important for microbial pathogenicity and growth. Both are attached to the same site on the cell surface and their relative abundance is balanced to maintain homeostasis. We will study the prototypical SpaA- pilus…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.