NIH R01 · 2025
Regulation of HSV latency by Polycomb Silencing
Project Summary/Abstract Reactivation of viruses from latent infection can result in series disease. In addition, latent infections are a barrier to curing certain viral diseases. For the persistent herpesvirus, Herpes Simplex Virus (HSV), the mechanisms that regulate entry of the virus into a latent infection are not known. The formation of heterochromatin on the viral genome in neurons has long been hypothesized to contribute to suppressing gene expression for latency establishment. However, no functional studies have yet identified a role for heterochromatin formation as a mechanism to promote entry into latency or maintain a latent infection. There are multiple different types of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.