NIH R01 · 2024
Characterizing proteasome-substrate interactions by mass spectrometry proteomics
PROJECT SUMMARY This application features a close collaboration between bioanalytical (Dr. Reilly, Indiana University) and bio- chemistry (Dr. Matouschek, University of Texas, Austin) research groups aimed at improving our understanding of the ubiquitin-proteasome protein degradation system. The investigators contribute complementary expertise and experience in a variety of disciplines ranging from proteomics, protein bioinformatics, analytical chemistry and instrumentation, to biochemistry, molecular biology and cell biology. At Indiana University, cross-linking mass spectrometry will be combined with biochemical and genetic assays to characterize the interaction between the proteasome and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.