NIH R01 · 2024
Extracellular matrix in vertebrate hematopoietic stem cell specification
(PLEASE KEEP IN WORD, DO NOT PDF) Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Hematopoietic stem cells (HSCs) are the self-renewing, tissue-specific stem cells in vertebrates that regenerate definitive hematopoietic lineages over the life of the individual. HSC transplant is a major treatment modality for leukemia and some non-malignant hematologic diseases including sickle cell disease, as well as a platform for delivery of gene therapy. Understanding the complete set of normal signals involved in embryonic specification of HSCs remains elusive. To identify missing inputs, we have been investigating…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.