NIH R01 · 2025
Membrane potential and Calcium Signaling in Neutrophil Development and Inflammation
PROJECT SUMMARY Neutrophils are essential for host defense against bacteria, however toxic neutrophil mediators such as reactive oxygen radicals, granule enzymes and neutrophil extracellular traps contribute the pathogenesis of acute and chronic inflammatory diseases. While the ability of neutrophils to phagocytose and kill pathogens has been known for over 100 years, our knowledge of the molecular mechanisms guiding neutrophil activation lags significantly behind that of other immune cells, precluding the development of strategic therapeutic interventions targeting neutrophils. Our long-term goal is to define the mechanisms by which ion channels and associated signaling pathways regulate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.