NIH R01 · 2025
Mechanisms of HIV accessory protein mediated control of NK cell function
PROJECT SUMMARY Despite their potent innate cytotoxic activity, NK cells are unable to completely control HIV, however, their depletion enhances acute viremia, and their proliferation during hyperacute infection is associated with better control of infection, suggesting they do apply immune pressure. In vitro, infected cells that survive NK cell exposure have higher levels of MHC-I, suggesting that the MHC-Ilow cells are preferentially eliminated due to “missing self”. However, our preliminary data demonstrates that while genetic ablation of the HIV accessory protein, Nef, rescues MHC-I surface expression on infected cells, these cells are not completely protected from killing, suggesting…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.