Clayson Lab

University of South Florida

NONE

Tampa · United States

NIH-funded
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NIH R01 · 2024

PsyRAT: Extensible Open-Source Software for Applying Generalizability Theory to Assess Psychometric Reliability of Trial-Wise Scores and Optimize Tasks for RDoC

PROJECT SUMMARY/ABSTRACT Neural biomarkers are an important focus of the NIMH Research Domain Criteria (RDoC) initiative, and they are increasingly used in the context of genomic studies and clinical trials. The use of biomarkers with strong psychometric reliability increases the likelihood of finding replicable effects, improves the validity of their interpretation, and decreases the likelihood of missing real phenomena. Although fundamental psychometric principles have long been a prominent concern among studies that use self-report measures, these principles are underappreciated in studies of psychopathology that use biological measures. This lack of attention to reliability limits the…

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