NIH R01 · 2025
Structure and Mechanism of the Glucose-6-Phosphatase Catalytic Subunit 1
Project Summary This proposal requests support for investigating the structure and enzymology of glucose-6-phosphatase catalytic subunit 1 (G6PC1), an integral membrane protein of the phosphatidic acid phosphatase type 2 (PAP2) superfamily expressed in the ER that catalyzes glucose production in the liver. Unregulated G6PC1 activity contributes to diabetes pathology by driving increases in hepatic glucose production and fasting blood glucose. In contrast, mutations in G6PC1 that impair activity cause glycogen storage disease type 1a (GSD type 1a), which is characterized primarily by severe hypoglycemia. Despite its physiological relevance to glucose metabolism, the structural basis of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.