NIH R01 · 2025
Structural basis for allosteric regulation of RyR1
PROJECT SUMMARY/ABSTRACT: Ryanodine receptor-mediated calcium release plays an essential role in muscle contraction, and disruption of calcium homeostasis in excitable tissues caused by RyR-mediated calcium leak causes several genetic diseases, as well as contributing to the progressive loss of muscle function that occurs with aging. RyRs are tetrameric ion channels of unusually large size, with each subunit bearing a large cytosolic region that acts as a scaffold for the binding of allosteric modulators, which regulate the channel by binding at sites far from the transmembrane pore. The mechanistic basis of long-range allosteric modulation of RyR1 activity is not well understood.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.