NIH R01 · 2025
Using artificial intelligence to bridge human and murine studies of lupus nephritis progression
PROJECT SUMMARY Lupus nephritis (LN) is the most common severe manifestation of systemic lupus erythematosus (SLE) Disease progression is associated with tubulointerstitial hypoxia and metabolic dysfunction, capillary rarefaction, accumulation of immune infiltrates and fibrosis. Complete remission rates in patients with LN are <50% (and often <30%) even in the setting of rigorous clinical trials and responses cannot currently be predicted by clinical and histologic features at initial biopsy. We currently have insufficient understanding of why clinical outcomes do not always correlate with histologic changes, why only some patients with interstitial kidney inflammation progress to ESRD, and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.