Clark Lab

University of Florida

NEUROSCIENCES

Gainesville · United States

NIH-funded
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NIH R01 · 2024

Cognitively engaging walking exercise and neuromodulation to enhance brain function in older adults

Declines in cognitive function and walking function are highly intertwined in older adults. For instance, lower executive function exacerbates conversion to Alzheimer’s disease and is also associated with slow walking speed, instability, and falling. In turn, low levels of walking activity are a risk factor for age-related cognitive decline including Alzheimer’s disease. Combinatorial interventions that target both cognition and walking function may break this vicious cycle. Prefrontal networks are a crucial intervention target due to their role in executive function, which underlies performance of both complex cognitive tasks and complex walking tasks. Our research targets prefrontal…

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