NIH R01 · 2025
Regulation of Retinal Development by RNA molecules
PROJECT SUMMARY The prevailing hypothesis in biology is encapsulated by the ‘central dogma’, which posits that our heritable genetic traits are encoded by DNA, transcribed into an RNA intermediate, and translated into functional proteins. However, this model fails to incorporate the contributions of the prevalent expression of non-coding RNA transcripts. Our recent profiling of the developing retina of humans and mice highlighted widespread and temporally dynamic expression of long non-protein coding RNAs (lncRNAs). lncRNAs play essential roles in the regulation of transcriptional and epigenetic programs during cell fate decisions, including those of the developing retina. One mechanism by…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.