NIH R01 · 2025
Cerebrospinal fluid dynamics in Huntington's disease
PROJECT SUMMARY The overall objective of this work is to apply innovative neuroimaging methods of cerebrospinal fluid (CSF) production, transport, and resorption in patients with Huntington’s disease (HD) to test fundamental hypotheses regarding the sequelae of aberrant neurofluid circulation in HD participants. New intrathecally administered ASOs have gained great interest as a disease-modifying treatment in HD, and yet in HD, these interventions have resulted in increases in neurofilament light protein (NfL) levels, and greater ventricular volumes. Importantly, post-hoc data indicates some may benefit from these interventions, and new trials are being developed. Heterogeneity in treatment…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.