NIH R01 · 2025
Systems Genetics of Vascular Smooth Muscle Phenotypes
PROJECT SUMMARY Coronary artery disease (CAD) remains the leading cause of death in the Western world despite significant advances in early detection and extensive use of lipid-lowering and anti-hypertensive drugs. To date, no single drug has been developed to target the primary disease process in the vessel wall. A complete understanding of the disease susceptibility is urgently needed to develop additional therapies. Common forms of atherosclerosis involve environmental factors, hundreds of genetic variations, and their interactions, each of which exert a relatively small effect on disease susceptibility. The most recent genome-wide association study (GWAS) in nearly six hundred fifty…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.