NIH R01 · 2024
Project Summary/Abstract Cocaine, the second highest used illegal drug in the US, reduces CNS immune responses to HIV-1, increasing the severity and onset of HIV-1-mediated neurotoxicity. Astrocytes are the first line of defense against toxicity in the CNS and initiate inflammatory responses to HIV-1 and antiviral activity following cocaine exposure (33); however, uncontrolled inflammation and the failure to control HIV-1 replication is a continued problem. Mitochondrial antiviral signaling protein (MAVS), together with absent in melanoma 2 (AIM2)-like receptor inflammasomes, their interactions, crosstalk and dual scaffolding could be key mechanisms triggering inflammatory and antiviral…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.