NIH R01 · 2025
Synaptic activity-driven Abeta generation and aggregation
PROJECT SUMMARY/ABSTRACT: Numerous biochemical and biophysical studies have demonstrated that amyloid-β (Aβ) aggregates into toxic oligomers and fibrils when the concentration of the peptide is elevated and the pH is low (Paredes-Rosan et al. 2019; Zhao et al. 2018). Aβ aggregates can be detected neuron throughout the endo-lysosomal pathway (Brewer et al. 2020) where pH ranges from 4.5-6.5 which are prime conditions for Aβ to aggregate. However, what physiological processes influence Aβ aggregation in vivo within this compartment remain unknown. Elevated synaptic activity increases the formation of Aβ within endosomes before it is secreted into the brain interstitial fluid (ISF) (Cirrito et…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.