NIH R01 · 2024
Disruption of restorative processes in chronic stress: An integrated cellular approach
Abstract Chronic stress is pervasive in our society and linked to a reduced quality of life and increased risk for developing chronic diseases. Treatment options, including changes in lifestyle, exercise, and anxiolytics, are only partially effective and would benefit from a deeper understanding of the cellular mechanisms underlying the negative effects of chronic stress on the brain. Here we start by focusing on key restorative processes that occur during the inactive phase - the light period in rodents and the dark period in humans - when animals are asleep and for many hours brain activity is characterized by the presence of spindles and slow waves. These restorative processes involve…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.