NIH R01 · 2025
Deciphering the role of noncoding variation in the pathogenesis of multiple sclerosis
Project Summary Multiple sclerosis (MS) is a chronic, inflammatory condition of the brain and spinal cord mediated largely by pathogenic T cell responses to myelin antigens, resulting in demyelination of the central nervous system (CNS). Myelin-reactive T cells are also crucial for induction of the experimental autoimmune encephalomyelitis (EAE) mouse model of MS. Studies of MS and EAE implicate CD4 T helper (Th) cells in disease pathogenesis, including pro-inflammatory Th17 and Th1 cells. In this regard, the disease-promoting ability of these T cell subsets stems from both their capacity to target and infiltrate the CNS and their pro-inflammatory effector function. An interplay between…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.